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KW-6356 research product
Lot339DRTestedAug 29, 2026Chromate · Independent third-party laboratory

Neurocognitive Research

KW-6356

397.4 g/mol

KW-6356 is a rare GMP liquid research compound containing 5MG per ML in a 30ML format.

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Your purchasing batch
339DR
Certificate on record for this lot

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Verified test results

Every batch, independently verified.

Each batch is analyzed by Chromate, an independent third-party laboratory, before release. Below is the report for lot 339DR, summarized from the certificate the lab published.

CHR
Chromate
Independent third-party laboratory
PASS
Certificate of Analysis · #38848
Lot
339DR
Tested
Aug 29, 2026
Measured
5.139mg/mL
Independent third-party lab
MethodQualitative and quantitative chemical analysis by RP-HPLC with UV detection
IssuedAug 29, 2026 · signed by the principal chemist
VerifyAccess code printed on the certificate, checked at chromate.org/verify
KW-6356 certificate of analysisOpen the 339DR certificate
View the signed certificate →
Certificate results✓ 2 passed · 1 reported
Appearance
Per certificate
Clear liquid
PASS
Identity
HPLC
KW-6356
PASS
Net content
HPLC
5.139mg/mL
5MG/ML
REPORTED

Every batch on record

This lot ships under its own published certificate. Open any certificate below, exactly as the lab released it.

Open the COA portal →
Latest published
339DR

IdentityKW-6356

Measured5.139mg/mL

TestedAug 29, 2026

View certificate →

Side by side

How Disguised compares.

Disguised
Typical supplier
Per-batch third-party COA
Yes
Rarely provided
Independent third-party testing
Yes
Inconsistent
HPLC purity verified
Yes
Often unverified
Made & tested in the USA
Yes
Often overseas
Discreet, tracked shipping
Yes
Varies

Technical specifications

Compound Information

Read the KW-6356 research guide
Molecular Profile

What is KW-6356?

Molecular FormulaC₂₀H₁₉N₃O₄S
Molecular Weight397.4g/mol
Storage Requirements

Stability information.

Do not freezeProtect from lightKeep the vial closed
2–8°C
Refrigerate after opening
Refrigerate once the seal is broken and keep it protected from light.
15–25°C
Unopened, as shipped
Room temperature is acceptable before opening. Do not freeze.

Peer-reviewed literature

The research behind this compound, cited in full.

Every reference below is a published, peer-reviewed record, linked to its PubMed entry. Provided for educational reference only - not product claims.

01Clinical pharmacology in drug development · 2024Population Pharmacokinetics of the Novel Adenosine A(2A) Antagonist/Inverse Agonist KW-6356 and Its Active Metabolite Following Single and Multiple Oral Administration in Healthy Individuals and Patients with Parkinson's DiseaseTayama T, et al.02Parkinsonism & related disorders · 2023Randomized controlled trial of KW-6356 monotherapy in patients with early untreated Parkinson's diseaseMaeda T, et al.03Molecular pharmacology · 2023In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A(2A) Receptor Antagonist/Inverse AgonistOhno Y, et al.04Clinical pharmacology in drug development · 2023Safety, Tolerability, and Pharmacokinetics of the Novel Adenosine A(2A) Antagonist/Inverse Agonist KW-6356 Following Single and Multiple Oral Administration in Healthy VolunteersTayama T, et al.05Journal of pharmacological sciences · 2023The adenosine A(2A) receptor antagonist/inverse agonist, KW-6356 enhances the anti-parkinsonian activity of L-DOPA with a low risk of dyskinesia in MPTP-treated common marmosetsOhno Y, et al.

Important research notice

Not for human, veterinary, or food use. This product is sold exclusively for laboratory research purposes. It is not intended to diagnose, treat, cure, or prevent any disease, and has not been evaluated by the FDA.

All referenced publications and registries are sourced from peer-reviewed journals and official registries. They are provided for educational reference only and are not product claims.

By purchasing, you confirm you are a qualified researcher and will handle this product in accordance with all applicable laws and regulations.

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The lot on this page links to the signed certificate for that batch.

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View Full Product Description

KW-6356: Rare 5MG/ML 30ML GMP Research Solution

KW-6356 is a rare GMP liquid research compound containing 5MG per ML in a 30ML format, designed for laboratory investigations involving adenosine A2A receptor pathway research, dopaminergic system interaction models, motor-pathway signaling, neurochemical balance, CNS receptor selectivity, and advanced nootropic pathway comparison studies.

Disguised Alpha KW-6356 is positioned as a specialized research solution for investigators working beyond common nootropic compounds. This is not a standard commodity listing. KW-6356 is a rare pathway-specific research compound supplied in a finished GMP liquid format with internal QA review and direct in-house fulfillment.

Rare A2A Receptor Pathway Research Compound

KW-6356 stands apart from typical CNS research compounds because of its focus on adenosine A2A receptor pathway activity and dopaminergic system interaction models. This makes it especially relevant for advanced research into receptor cross-talk, motor-pathway signaling, and neurochemical balance.

Formula Details

Compound: KW-6356
Concentration: 5MG/ML
Total Volume: 30ML
Total Content: 150MG
Format: Rare GMP liquid research solution
Research Focus: Adenosine A2A receptor signaling, dopaminergic interaction models, CNS pathway selectivity, and motor-pathway research.

A2A Receptor Research

Studied in models involving adenosine A2A receptor signaling, receptor selectivity, and CNS pathway modulation.

Dopamine Interaction Models

Relevant to research involving adenosine-dopamine pathway interaction, neurochemical balance, and motor signaling.

Rare GMP Liquid Format

Produced as a finished 5MG/ML GMP liquid research solution with formulation review and internal QA.

Why KW-6356 Matters in Research

KW-6356 is studied in advanced research models involving adenosine A2A receptor pathway activity, CNS receptor selectivity, dopaminergic interaction models, neurochemical signaling balance, and motor-pathway regulation.

Adenosine A2A signaling is often studied in relation to dopaminergic system behavior, making KW-6356 relevant to research models examining receptor cross-talk, pathway selectivity, locomotor signaling, and central nervous system modulation.

The 5MG/ML 30ML format gives researchers a rare finished liquid preparation model with 150MG total KW-6356 in a GMP research solution designed around clarity, consistency, and professional handling.

  • Rare KW-6356 GMP research solution
  • 5MG/ML concentration in a 30ML format
  • 150MG total KW-6356
  • Studied in adenosine A2A receptor pathway research
  • Relevant to dopaminergic interaction and CNS receptor selectivity models
  • Built for advanced nootropic and motor-pathway comparison research

Why Our Quality Process Is Different

Rare liquid research compounds require more oversight than common capsule or powder products. Concentration clarity, carrier compatibility, compound presentation, documentation, labeling accuracy, storage expectations, and finished-product handling all matter.

Disguised Alpha reviews KW-6356 as a specialized GMP liquid research product with attention to formulation consistency, finished-bottle presentation, product documentation, internal QA, and direct fulfillment accountability.

  • Rare GMP liquid production standard
  • Finished-product presentation review
  • Concentration and labeling clarity
  • Product documentation and formulation checks
  • Internal quality assurance before release
  • Direct in-house fulfillment with no anonymous 3PL handling

Verify Our Claims

We believe researchers should be able to verify the standards we speak about. Learn more about the independent laboratories we work with below.

Visit ILS Labs Visit Chromate

The Disguised Alpha Standard

Disguised Alpha is built around direct accountability. Every order is processed, inspected, packaged, and shipped by our in-house team instead of being passed off to a third-party logistics warehouse.

This gives us tighter control over formulation quality, fulfillment accuracy, packaging standards, storage conditions, and customer experience. Our goal is not to be the cheapest research supplier. It is to provide rare, professionally handled compounds with real quality oversight behind them.

Research Use Disclaimer: This product is sold strictly for laboratory research purposes only. It is not intended for human consumption, medical use, diagnostic use, therapeutic use, Parkinson’s treatment use, neurological treatment use, cognitive enhancement use, stimulant use, supplement use, or the treatment, prevention, or diagnosis of any disease.

Questions about KW-6356

Is KW-6356 an antagonist or an inverse agonist?

Both, in its developer's words: Kyowa Kirin describes it as an adenosine A2A receptor antagonist/inverse agonist, meaning it blocks adenosine binding and also inhibits the receptor's constitutive activity. In vitro it bound the human A2A receptor with sub-nanomolar affinity, dissociated very slowly and showed insurmountable antagonism.

How is KW-6356 different from istradefylline?

They come from the same company, now Kyowa Kirin, and both target the adenosine A2A receptor. Istradefylline is an alkylxanthine that behaved as a surmountable antagonist in vitro, while KW-6356 is a thiazole that showed insurmountable antagonism and inverse agonism; co-crystal structures tied its inverse agonism to contacts with His250 and Trp246. Istradefylline was FDA approved in 2019 as Nourianz.

Has KW-6356 been tested in clinical trials?

Yes, as research history. Kyowa Kirin ran two phase 1 studies in healthy Japanese and White volunteers, with randomized, double-blind, placebo-controlled and open-label parts, that measured its pharmacokinetics, and a double-blind, placebo-controlled phase 2 trial in Japan that randomized and treated 168 people with early, untreated Parkinson's disease and measured change in MDS-UPDRS Part III scores over 12 weeks.

Is KW-6356 FDA approved?

No. Drugs@FDA lists no product under KW-6356 or its nonproprietary name, sipagladenant. Kyowa Kirin, which discovered it, announced on 15 July 2022 that it was discontinuing the clinical development program, citing the global regulatory landscape, development hurdles and timelines for potential market entry, and a 2023 review lists it as no longer in development for Parkinson's disease.

Batch documentation for KW-6356

Match the selected product option and assigned shipping lot to the corresponding report in the COA portal. Check the compound or components, sample identification, test date, methods and results actually reported. Results for another lot or formulation are not a substitute.

Does a purity percentage state the amount in the container?

No. Analytical purity and measured content are different measurements. Compare labeled quantity with measured content only where the report provides a compatible result and unit.

Read the KW-6356 research reference. For batch documentation or formulation questions, contact Disguised Alpha.

Additional product details

KW-6356 is a rare GMP liquid research compound containing 5MG per ML in a 30ML format.

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