What is chonluten?
Chonluten is the synthetic tripeptide Glu-Asp-Gly (EDG), one of the short peptides that V. Kh. Khavinson and colleagues at the Saint Petersburg Institute of Bioregulation and Gerontology call peptide bioregulators. The group's 2022 review table lists it as a gastroprotector and stress protector (Khavinson et al., 2022). The only paper whose PubMed abstract uses the name calls it a bronchial bioregulator derived from lung (Avolio et al., 2022), and the institute's own papers code the sequence T-34 (Voicekhovskaya et al., 2012).
The record is very small. It comes almost entirely from the institute and its partners and covers cells, tissue explants and rats; both rat papers appeared in the English edition of a Russian journal. It is not an approved drug in the United States (no Drugs@FDA record, October 2026). Disguised Alpha does not currently list chonluten; this page is a literature reference for laboratory researchers. Nothing on this page is guidance for use in people.
Chonluten reference data
| Property | Value |
|---|---|
| Name | Chonluten |
| Also called | Glu-Asp-Gly, EDG, H-Glu-Asp-Gly-OH, L-glutamyl-L-aspartyl-glycine, glutamyl-aspartyl-glycine, T-34 (the institute's code) |
| Sequence | Glu-Asp-Gly: L-glutamic acid, L-aspartic acid and glycine joined by peptide bonds, with a free amino terminus and a free carboxyl terminus |
| Compound class | Synthetic tripeptide; a short peptide bioregulator from the Khavinson group, listed as a gastroprotector and stress protector |
| Molecular formula | C₁₁H₁₇N₃O₈ |
| Molecular weight | 319.27 g/mol (monoisotopic mass 319.10 Da) |
| PubChem | CID 194641, filed as glutamyl-aspartyl-glycine |
Formula, weight, stereochemistry and synonyms, T-34 tripeptide among them, are from PubChem CID 194641, which has no record under the name chonluten. The methods of the THP-1 study (Avolio et al., 2022) and the group's review table (Khavinson et al., 2022) tie the name to the sequence.
What the research covers
Published work on chonluten falls into six areas, and each summary below names its model. Only one PubMed abstract uses the name; most papers use the sequence or the code T-34.
A stomach ulcer model in rats, as T-34
The institute's one indexed animal study ran under the code T-34. Its abstract reports that the peptide normalized the synthesis of antioxidant and anti-inflammatory proteins that change as a gastric ulcer develops, by regulating their genes (Khavinson et al., 2012).
PubMed's subject indexing lists male Sprague-Dawley rats, chemically induced stomach ulcers, cystamine, Helicobacter pylori, clarithromycin, HSP70, two nitric oxide synthases and the NF-κB subunit RelA, and files the peptide as glutamyl-aspartyl-glycine. The group's reviews cite this paper for the gastroprotector label (Khavinson et al., 2022) and summarize it as regulating the c-Fos, HSP70, SOD, COX-2 and TNF-α genes (Khavinson et al., 2020). Model: rats.
Skin explants from young and old rats
The institute compared five tripeptides in organotypic skin cultures from young and old rats: T-32 (Glu-Asp-Ala), T-33 (Glu-Asp-Arg, the pinealon sequence), T-34 (Glu-Asp-Gly), T-36 (Glu-Asp-Pro) and T-38 (Lys-Glu-Asp, the vesugen sequence). In explants from young rats, every peptide except T-34 stimulated cell proliferation. In explants from old rats, the abstract singles out T-38 (Voicekhovskaya et al., 2012). Model: rat skin explants.
Human monocytes and macrophages
A University of Chieti group in Italy, with Khavinson as a co-author, tested chonluten beside epitalon, vilon, thymogen and thymalin in THP-1, a human monocytic leukemia cell line, at 100 ng/mL each with or without bacterial lipopolysaccharide (LPS). The abstract reports that all five raised tyrosine phosphorylation of mitogen-activated kinases and that chonluten inhibited TNF production by monocytes exposed to LPS.
The full text adds that only chonluten raised the share of apoptotic cells, to about double the value with the others, and that monocytes incubated with it showed a slight TNF release, which the authors read as a tolerance mechanism. In macrophage-like cells the peptides lowered LPS-stimulated TNF and IL-6, and chonluten raised STAT1 phosphorylation (Avolio et al., 2022). Model: human cell line.
Transporter docking
Two modeling studies from the group docked the tripeptide into amino acid and peptide transporters. The 2022 review ranked it among the strongest predicted binders of LAT1, an amino acid transporter (Khavinson et al., 2022). A 2023 study of 26 short peptides ranked it second for LAT1, after EDR. Its abstract links a possible antitumor effect of EDG to transporter inhibition, but the paper cites antitumor work only for other peptides (Khavinson et al., 2023), and we found none for EDG. Model: computer docking; scores, not measurements.
An earlier, unrelated identification
Outside the bioregulator program, a Japanese team in 1980 isolated an acidic tripeptide from a dialysate it described as neurotoxic, identified it as H-Glu-Asp-Gly-OH against a synthetic standard, and reported that it inhibited lactate dehydrogenase activity (Abiko et al., 1980). Details are from the publisher's abstract; PubMed has none. Model: chemical isolation.
Review statements without primary data
The group's 2020 review states that the tripeptide was used in chronic obstructive pulmonary disease and chronic bronchitis, including people with asthmatic chronic bronchitis on standard care, and under low oxygen pressure (Khavinson et al., 2020). The only reference attached to that passage is the 2012 rat paper, and no primary report behind these statements is indexed in PubMed. Model: none; a review.
Key studies
- Avolio F, et al. "Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line." Int J Mol Sci. 2022. PMID 35408963. DOI 10.3390/ijms23073607. Human THP-1 cells.
- Khavinson VKh, et al. "Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins." Bull Exp Biol Med. 2012. PMID 22803148. DOI 10.1007/s10517-012-1590-2. Rats; peptide coded T-34.
- Voicekhovskaya MA, et al. "Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats." Bull Exp Biol Med. 2012. PMID 22803085. DOI 10.1007/s10517-012-1527-9. Rat skin explants.
- Khavinson VK, et al. "Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters." Biomolecules. 2023. PMID 36979488. DOI 10.3390/biom13030552. Computer docking.
- Abiko T, et al. "Characterization of an acidic tripeptide in neurotoxic dialysate." Chem Pharm Bull (Tokyo). 1980. PMID 7408052. DOI 10.1248/cpb.28.1629. Isolation from dialysate.
Handling and storage of lyophilized chonluten
General laboratory practice for lyophilized short peptides, covered in the peptide storage guide and the peptide reconstitution guide:
- Keep the sealed powder dry, at -20°C and protected from light, and let a cold vial reach room temperature before opening.
- With two acidic side chains and no basic one, it is an acidic peptide; the reconstitution guide notes that these dissolve best in basic solutions. Dissolve it in water before adding any buffer, and record the pH.
- It has no cysteine, methionine or tryptophan, the residues most prone to oxidation, but the storage guide lists aspartic acid sites among the features that shorten life in solution. Make solutions fresh, split them into single-use aliquots, keep them at 2 to 8°C protected from light and avoid freeze-thaw cycles.
- Confirm identity by mass: C₁₁H₁₇N₃O₈, monoisotopic 319.10 Da.
Frequently asked questions
What is chonluten?
Chonluten is the synthetic tripeptide Glu-Asp-Gly, a short peptide bioregulator from Khavinson's group in Saint Petersburg (Khavinson et al., 2022). It has been studied mainly in a human cell line, rat skin explants and rats, and in no indexed study in people.
Is chonluten a peptide?
Yes. It is a tripeptide of glutamic acid, aspartic acid and glycine with free ends (PubChem CID 194641). It is the epitalon sequence, Ala-Glu-Asp-Gly, without the first alanine, and the two were tested side by side in THP-1 cells (Avolio et al., 2022).
Is chonluten the same as T-34?
Yes, by sequence. The institute codes Glu-Asp-Gly as T-34 (Voicekhovskaya et al., 2012), PubChem and the National Library of Medicine list T-34 tripeptide as a synonym, and the rat stomach ulcer study used that code (Khavinson et al., 2012).
Is chonluten studied for the stomach or the lungs?
Both labels appear. The group's 2022 table calls it a gastroprotector and stress protector (Khavinson et al., 2022), and the institute's only indexed animal study used a stomach ulcer model. The Italian cell study calls it a bronchial bioregulator (Avolio et al., 2022). We found no indexed study of it in lung tissue.
Has chonluten been tested in people?
Not in any study indexed in PubMed (search of 12 October 2026). A 2020 review from the group describes use in people with chronic bronchitis but attaches no trial report to that statement (Khavinson et al., 2020). The only human cells exposed to it are a leukemia-derived cell line.
Does Disguised Alpha sell chonluten?
Not currently. Related short peptides in the catalog include Epitalon (Ala-Glu-Asp-Gly), Pinealon (Glu-Asp-Arg) and Vesugen (Lys-Glu-Asp).
Related compounds and guides
- Peptide bioregulators explained
- Peptide bioregulators list, A to Z
- Epitalon research guide: Ala-Glu-Asp-Gly
- Pinealon research guide: Glu-Asp-Arg, code T-33
- Vesugen research guide: Lys-Glu-Asp, code T-38
All Disguised Alpha products are for laboratory research only and are not for human consumption.